2021 CARDIAC PHYSIOME
VIRTUAL meeting. REGISTRATION is FREE.
| DAY 1 WEDNESDAY NOV 10 TIME ZONE: US EASTERN (EST) | |
| I. CiPA (Comprehensive in vitro Proarrhythmia Assay) Satellite Meeting 2021 (If you aren’t familiar with CiPA, or its in-silico modelling aspects, you may wish to review the FDA team’s publication on the modelling aspects here: https://doi.org/10.1002/psp4.12423) | |
| 9:00 – 9:30 | Introduction CiPA Welcome/Aims Gary Mirams (University of Nottingham) An update on CiPA Progress David Strauss (FDA) |
| 9:30 – 10:10 | Theme 1: Incorporating Improvements Joint talk: Zhihua Li (FDA) Principles for regulatory acceptance & Ken Wang (Roche) An example of ongoing work on comedications 10mins Expanded Q&A |
| 10:10 – 10:20 | Break |
| 10:20 – 11:10 | Theme 2: Binding & Kinetics Dominic Whittaker (University of Nottingham) “Exploring models of drug-hERG channel interactions” Adam Hill (Victor Chang Cardiac Research Institute) “Next steps for in-silico risk prediction” |
| 11:10 – 12:20 | Theme 3: Risk in Subpopulations Zhilin Qu (UCLA) “An in-silico platform for cardiac arrhythmia risk prediction” Stefano Morotti (UC Davis) “Sex-Specific Classification of Drug-Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning” |
| 12:20 – 12:40 | Break |
| 12:40 – 13:15 | Q&A for Pre-recorded CiPA Talks (pre-recorded talks) |
| 13:15 – 13:30 | Break |
| 13:30 – 15:00 | CARDIAC PHYSIOME Poster Session 1 (posters) |
| 15:00 – 15:50 | Roundtable Discussion Discussion panelists: David Strauss, Zhihua Li, Eleonora Grandi, Trine Krogh-Madsen Gary Mirams (University of Nottingham) – summing up and future challenges |
| 15:50 – 16:00 | Break |
| II. Quantitative Systems Pharmacology (QSP) & Quantitative Systems Toxicology (QST) Session (under the joint auspices of Cardiac Physiome/ACOP12) Moderator: Kylie Beatie (GSK) | |
| 16:00 – 16:05 | Opening remarks: Cardiac Physiome + ACOP/ISOP organizers |
| 16:05 – 16:20 | Keynote Talk by CJ Musante (Pfizer) – The When and Why of Cardiovascular QSP & QST: An Industry Perspective |
| 16:20 – 16:55 | Panel Discussion with Industry QSP&QST representatives including on validation framework, collaboration opportunities and career opportunities for young trainees Limei Cheng (BMS) Valeriu Damian (GSK) CJ Musante (Pfizer) Amy Pointon (AstraZeneca) Christopher Pollard (Certara) Scott Siler (DILIsym, Simulations Plus) |
| 16:55 – 17:00 | Break |
| III. Industry Software/Computational Methodologies Moderator: Steven Niederer (King’s College London) | |
| 17:00 – 17:15 | Keynote talk by Pras Pathmanathan (FDA) – When can we trust cardiac simulations? |
| 17:20 – 18:00 | Panel Discussion with Industry Software Developers on novel methodology, case studies and collaboration opportunities, career opportunities for young trainees James Kozloski (IBM) Nathalie Virag (Medtronic) Pras Pathmanathan (FDA) Christopher Rackauckas (Julia) Karim El Houari (Ansys) Tiziano Passerini (Siemens) Gernot Plank (University of Graz) Karl D’Souza (Living Heart Project, Dassault Systemes) |
| DAY 2 THURSDAY NOV 11 TIME ZONE: US EASTERN (EST) | 2021 Cardiac Physiome Workshop Latest Insights into Electro-Mechano-Energetic Coupling in the Heart |
| 8:45 – 9:00 | Welcome by Cardiac Physiome Workshop Organizers: Anna Sher (Pfizer), Thomas Heldt (MIT), David Nickerson (University of Auckland) Opening Remarks by Morrie Birnbaum (Pfizer) |
| 9:00 – 9:30 | Keynote talk by Declan O’Regan (Imperial College London) Title: New approaches to cardiovascular disease research using imaging and AI Chairperson: Tammo Delhaas (Maastricht University) |
| 9:30 – 10:40 | Session 1: CARDIAC METABOLISM & METABOLIC DISEASES Moderator: Dan Beard (University of Michigan) Speaker/panelist 1: Jason Bazil (Michigan State University) – Mitochondrial calcium overload and its effects on energy metabolism Speaker/panelist 2: Dunja Aksentijevic (Queen Mary University of London) – Immunometabolic cross-talk in the inflamed diabetic heart Panelist 3: Michael Shattock (King’s College London) Panelist 4: Gary Lopaschuk (Alberta University) Panelist 5: Fabio Recchia (Scuola Superiore Sant’Anna, Pisa, Italy) |
| 10:40 – 10:50 | Break |
| 10:50 – 12:00 | Session 2: CARDIAC MECHANICS AND MECHANO-ENERGETICS Moderator: Peter Kohl (University of Freiburg) Speaker/panelist 1: Bert Tanner (University of Washington) – Effects of sarcomere length and fibrosis on myocardial force production in tissue samples from donors and heart failure patients Speaker/panelist 2: Eva Rog-Zielinska (University of Freiburg) – Beat-by-beat cardiac T-tubular deformation drives luminal content exchange Panelist 3: Asuka Hatano (Tokyo University) Panelist 4: Paul Janssen (The Ohio State University) |
| 12:00 – 12:20 | Break |
| 12:20 – 13:25 | CARDIAC PHYSIOME Poster Session 2 (posters) |
| 13:25 – 13:30 | Break |
| 13:30 – 14:00 | Keynote talk by Denis Noble (University of Oxford) Title: How did the Cardiac Physiome take off, and where should it be going? Chairperson: Peter Hunter (University of Auckland) |
| 14:00 – 15:10 | Session 3: CARDIAC ELECTRO-MECHANO-ENERGETIC COUPLING Moderator: Andrew McCulloch (University of California San Diego) Speaker/panelist 1: Viviane Timmermann (Freiburg University) – A computational model of mechano-electric coupling and mechano-energetics during acute ischemia Speaker/panelist 2: Adarsh Krishnamurthy (Iowa State University) – Data-driven computational modeling for cardiovascular mechanics Panelist 3: Pawel Swietach (University of Oxford) Panelist 4: Naomi Chesler (University of Wisconsin-Madison) Panelist 5: Olga Solovyova (Institute of Immunology and Physiology, Russian Academy of Sciences, Ekaterinburg) |
| 15:10 – 15:20 | Break |
| 15:20 – 16:30 | Session 4: HEART FAILURE Moderator: Russell Miller (Pfizer) Speaker/panelist 1: Stuart Campbell (Yale University) – Molecular mechanisms of the dilated cardiomyopathy-associated mutation TPM1 M8R Speaker/panelist 2: Aaron Aguirre (Massachusetts General Hospital, Harvard Medical School) – Intravital imaging of the coronary circulation at the cellular level in models of heart failure Panelist 3: Kenneth Campbell (University of Kentucky) Panelist 4: Kaivan Khavandi (GSK) |
| 16:30 – 16:50 | In Memory of Edmund Crampin Reminiscences by Vijay Rajagopal and Peter Hunter |
| DAY 3 FRIDAY NOV 12 TIME ZONE: US EASTERN (EST) | Cardiac Physiome 2021 Pharmacotherapy, Surgical Intervention and Looking Beyond the Heart |
| 9:00 – 9:30 | Keynote talk by Natalia Trayanova (Johns Hopkins University) Title: AI-Enabled Personalized Computational Cardiology Chairperson: Alexander Panfilov (Ghent University) |
| 9:30 – 10:40 | Session 5: ELECTROPHYSIOLOGY, ARRHYTHMIA, AND RISK STRATIFICATION Moderator: Jeremy Ruskin (Massachusetts General Hospital, Harvard Medical School) Speaker/panelist 1: Nele Vandersickel (Ghent University) – Applications of directed graph mapping (DGM) to analyze different types of cardiac arrhythmia Speaker/panelist 2: Patrick Boyle (University of Washington) – Towards better understanding of left atrial fibrosis as a common pathophysiological nexus between arrhythmogenesis and thrombogenesis Panelist 3: Collin Stultz (MIT) Panelist 4: Leon Glass (McGill University) Panelist 5: Alex Quinn (Dalhousie University) |
| 10:40 – 10:50 | Break |
| 10:50 – 12:00 | Session 6: CARDIAC SURGICAL INTERVENTIONS Moderator: Michael Sacks (Texas University) Speaker/panelist 1: Caroline Roney (King’s College London) – Predicting atrial fibrillation ablation outcome by combining population data and patient-specific models Speaker/panelist 2: Ellen Roche (MIT) – A moving target: Augmenting dynamic organ function with device-based approaches Panelist 3: Keith Herrmann (Boston Scientific in Minneapolis) Panelist 4: Elazer Edelman (MIT) Panelist 5: Steffen Leonhardt (RWTH Aachen, Helmholtz Institute) |
| 12:00- 12:20 | Break |
| 12:20 – 13:25 | CARDIAC PHYSIOME Poster Session 3 (posters) |
| 13:25 – 13:30 | Break |
| 13:30 – 14:00 | Keynote talk by Alison Marsden (Stanford University) Title: Towards personalized simulations of cardiovascular fluid solid growth Chairperson: Chae Hun Leem (University of Ulsam) |
| 14:00 – 15:10 | Session 7: STRUCTURAL CARDIAC DISEASES AND RARE DISEASES Moderator: Steven Niederer (King’s College London) Speaker/panelist 1: Stephanie Lindsey (Stanford University) – The use of tissue engineered vascular grafts in single ventricle palliation: Assessing the role of changing hemodynamic conditions Speaker/panelist 2: Francisco Sahli Costabal (Pontificia Universidad Católica de Chile) – Learning atrial fiber orientations and conductivity tensors from intracardiac maps using physics-informed neural networks Panelist 3: Jeffrey Saucerman (The University of Virginia) Panelist 4: Gabriel Brooks (Pfizer) |
| 15:10 – 15:20 | Break |
| 15:20 – 16:30 | Session 8: BEYOND THE HEART Moderator: Mellisa Hallow (University of Georgia) Speaker 1: Daniela Valdez-Jasso (University of California San Diego) – Arterial and right ventricular remodeling in pulmonary arterial hypertension Speaker 2: Ana Simon Chica (University of Freiburg) – Cardiac immune cells: electrophysiological considerations and leukocyte diversity in the heart Speaker: Elaine Chew (CNRS – STMS Lab (IRCAM)) – Musical expression and cardiac electrophysiology: Reciprocal interactions |
| 16:30 – 16:50 | Awards ceremony Moderator: Andrew McCulloch (University of California San Diego) John Jeremy Rice Early Career Innovation Award presented by Richard Gray (FDA) James B. Bassingthwaighte Young Investigator Best Poster Awards presented by Dan Beard (University of Michigan) |
| 16:50 – 17:00 | Closing remarks by Anna Sher (Pfizer), Thomas Heldt (MIT), and , David Nickerson (University of Auckland) |